Research summary 

The tumor microenvironment (TME) has become one of the most intriguing topics in cancer research. The ability to manipulate the TME has shown promising results in the development of cancer therapeutics especially in the

immunotherapy field. TME stromal cells display multifaceted anti and pro-carcinogenic roles underscoring the

importance of manipulating the TME for developing effective therapy. Within the TME, exosomes are key players mediating communication across stromal cells and provide cancer cells with essential cues that promote the carcinogenesis and metastasis processes. Thus, understanding how exosomes regulate the TME would provide valuable insight into how primary tumors define the secondary tissues for subsequent cancer metastasis.

Our research goal is to decipher the mechanism by which immune cells-derived exosomes mediate long distant
communication with secondary tissues to promote premetastatic niche formation as a basis to develop cancer biomarkers and exosome-based targeted therapy to prevent metastasis. Two research theme areas in exosomes medical research is of major interest:

1. Cancer therapeutics
The role of exosomes in reprograming distant organ’s stromal cells to form premetastatic niche as a basis to develop
exosomes-based targeted therapy in cancer to prevent metastasis.

2. Cancer biomarkers
The use of exosomes by means of liquid biopsy to develop tumor diagnostic and prognostic markers.

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